DTI Atlas Building

This is a collaborative page to discuss projects using DTI atlas building.

Neonate/pediatric imaging (control atlases)

Parameters:
sigma = 1.5
AtlasBuilder (instead of AtlasWerks)

General data directory
/conte_projects/CONTE_NEO/DTI-atlasBuilding/Neo90cases

Transformed images
/conte_projects/CONTE_NEO/DTI-atlasBuilding/workspace-goodlett
contains tensor fields (no suffix)
color fa
fa
md

Atlas tensor image
/conte_projects/CONTE_NEO/DTI-atlasBuilding/atlas/AtlasTensor.nrrd

Atlas feature image
/conte_projects/CONTE_NEO/DTI-atlasBuilding/Final/Average.raw

Krabbe's disease

• Data location: /NDRC/neo/krabbe_escolar
  • neonates: K4_01, K5_01, K6_01, K7_01, K8_01
  • K5 and K6 have followup: 02 at 6 months, 03 at 12 months, 04 at 20 month, 05 at 25 months
  • K7 has no follow up data, as deceased, K8 will have follow up
  • The DTI of the follow ups and K8_01 have not yet been processed

Paper Strategies

Major focus: Atlas-building procedure as a data-driven approach for generating hypotheses Basic approach

• Build healthy neonate atlas with voxel-wise Gaussian statistics and non-parametric statistics (histogram quantile score)
• Compare individual registered neonate cases with z-scores based on voxel-wise images
• Hypothesis testing to generate regions with possible changes for the Krabbe population
• Regression analysis incorporating motor and clinical assessment outcome

Possible submission: MMBIA 2007 (June 15 deadline)

Adult Fitness study

• 2 groups, age 60-75, difference in fitness activity (low vs regular), all controls, no major health problems
• Data location: /projects5/MarksDTI/
  • All available data has been preprocessed and tensor files in NRRD are already available

Casey's TODO Items

• Exclude non-controls from existing atlas statistics and generate new z-score images (by 4/22/07)
• Build healthy neonate atlas for Krabbe's using multi-resolution AtlasWerks (by 4/25/07)
• Produce z-scores for Krabbe cases to new neonate atlas (by 4/30/07)